With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. 738Nnucleophilic addition on Aldehyde and ketone groups Organic Chemistry by Carey and Giuliano -739 9. In this note, the basics in Bioorganic Chemistry, its inception and its today’s platform will be focused. Bio organic chemistry. Organic Chemistry by Carey and Giuliano -347 7. Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. 746 Reactions of carbonyl group with amines Organic Chemistry by Carey and Giuliano -751 10. 742 Nnucleophilic addition on Acetals and ketals Organic Chemistry by Carey and Giuliano -743 8. This note will describe the historical connection between organic chemistry, physical chemistry and biology in its introductory part.