More specifically, calcium salts may impair the absorption of fluoride. Ceftriaxone binds to calcium forming an insoluble precipitate. Metallic taste © 2005 - 2019 WebMD LLC. Calcium channel blocker overdose, beta-blocker overdose (off-label uses): Monitor hemodynamic response; monitor serum ionized calcium levels every 30 minutes initially then every 2 hours and maintain ionized calcium ~2 times the ULN; avoid severe hypercalcemia (ionized calcium levels >2 times ULN) (Kerns 2007). Hypocalcemia: Note: In general, IV calcium gluconate is preferred over IV calcium chloride in nonemergency settings due to the potential for extravasation with calcium chloride. Hypocalcemia (prompt increase in serum calcium levels) Consider therapy modification, Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Irritate or burning sensation if eyes or skin are exposed to calcium chloride dust. Drug Interactions Children >45 kg and Adolescents: IV: 0.2 to 0.3 mEq/kg/day or 10 to 20 mEq/day. Description Consider therapy modification, Phosphate Supplements: Calcium Salts may decrease the absorption of Phosphate Supplements. Calcium channel blocker toxicity: Infants, Children, and Adolescents: Dosage expressed in mg of calcium chloride: IV: 20 mg/kg/dose infused over 5 to 10 minutes; if effective, consider IV infusion of 20 to 50 mg/kg/hour (Kleinman 2010). This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Calcium chloride Contraindications. • Acidosis: Use with caution in patients with respiratory acidosis, renal impairment, or respiratory failure; acidifying effect of calcium chloride may potentiate acidosis. Alternative dosing: IV: 10 to 20 mg/kg/dose; maximum dose: 1,000 mg; repeat every 4 to 6 hours if needed. Enter your email & get your free copy here. Note: Routine use in cardiac arrest is not recommended due to the lack of improved survival (AHA [Neumar 2010]). Consider therapy modification, DOBUTamine: Calcium Salts may diminish the therapeutic effect of DOBUTamine. Sign Up to Receive Our Free Coroanvirus Newsletter. How to be and what to do if your arm is broken? Children >50 kg and Adolescents: IV: 10 to 20 mEq/day as an additive to parenteral nutrition solution. Not for IM or SubQ administration (severe necrosis and sloughing may occur). Management: Use of ceftriaxone is contraindicated in neonates (28 days of age or younger) who require (or are expected to require) treatment with IV calcium-containing solutions. It is also used to flavour pickles without increasing the sodium content in it. The popliteal muscle: functions, causes of injury, help, Fracture of the base of the skull. Cardiopulmonary arrest not associated with calcium channel blocker toxicity, hypocalcemia, or hyperkalemia. CALCIUM CHLORIDE Drug Name: Calcium Chloride Trade Name: Calcium Chloride, Calcium, CaCl2 Class: • Electrolyte replacement Mechanism of Action: • Increase the force of cardiac contractility, by initiating myofibril shortening • In normally functioning hearts calcium will produce positive inotropic CALCIUM CHLORIDE Class. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. • Hypokalemia: Use with caution in patients with severe hypokalemia as acute rises in serum calcium levels may result in life-threatening cardiac arrhythmias. However, if a severe manifestation of calcinosis cutis occurs, may initiate sodium thiosulfate antidote. Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. 401,Ghitorni,New Delhi,110030, +91-8800159666 Monitor therapy. People who are prone to allergies, it must be remembered that the high efficacy of the drug in the treatment is significantly reduced if it is used without a doctor's prescription or violate the recommended dosage. Calcium requirements are the same in pregnant and nonpregnant females (IOM 2011). Prescription drug information for thousands of brand, generic, and OTC medicines is available to registered members only. Calcium chloride contains 27.2% elemental calcium. Cardiac resuscitation (questionable value) Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Administering oral phosphate supplements as far apart from the administration of an oral calcium salt as possible may be able to minimize the significance of the interaction. What is a blood clot, and how is it dangerous? Beta-blocker overdose (off-label use): Based on limited data: IV: Initial: Using a 10% solution: 20 mg/kg over 5 to 10 minutes (maximum: 1 to 2 g/dose); may repeat every 10 to 20 minutes for 3 to 4 additional doses or initiate a continuous infusion of 20 to 40 mg/kg/hour titrated to improve hemodynamic response (AHA [Vanden Hoek 2010]; DeWitt 2004; Kerns 2007). Last updated on May 31, 2020. • Appropriate product selection: Multiple salt forms of calcium exist; close attention must be paid to the salt form when ordering and administering calcium; incorrect selection or substitution of one salt for another without proper dosage adjustment may result in serious over or under dosing. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. It is also used to flavour pickles without increasing the sodium content in it. Note: Some recommend maintaining serum ionized calcium at a goal of twice normal (Kerns 2007). IV: For IV administration only. The safest method of introducing the solution is electrophoresis. • Ceftriaxone: Ceftriaxone may complex with calcium causing precipitation. Early/acute calcium extravasation: Initiate hyaluronidase antidote; remove needle/cannula; apply dry cold compresses; elevate extremity (Hurst 2004; Reynolds 2014). Avoid extravasation. Dosage expressed in mg of calcium chloride. They are normal constituents of the body fluids and are dependent on various physiological mechanisms for maintenance of balance between intake and output. It is provided in a 10 mL Unit of Use Syringe to facilitate prompt intravenous injection. May also inject hyaluronidase through the catheter that caused the infiltration (Reynolds 2014). Calcium chloride Adverse reactions. Calcium chloride should be administered Consider therapy modification, Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Note: In general, IV calcium gluconate is preferred over IV calcium chloride in nonemergency settings due to the potential for more severe extravasation with calcium chloride. Tetany: Infants, Children, and Adolescents: Dosage expressed in mg of calcium chloride: IV: 10 mg/kg over 5 to 10 minutes; may repeat after 6 hours or follow with an infusion with a maximum dose of 200 mg/kg/day. With an enlarged liver diet. All rights reserved. Monitor therapy, CefTRIAXone: Calcium Salts (Intravenous) may enhance the adverse/toxic effect of CefTRIAXone. calcitriol, ergocalciferol, calcium carbonate, epinephrine, sodium bicarbonate, Caltrate, Lokelma, patiromer, Vitamin D2, insulin regular. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register, 2002). Calcium chloride may be confused with calcium gluconate. Ceftriaxone should not be administered simultaneously with any calcium-containing solution via a Y-site in any patient. However, many people have no side effects or only have minor side effects. IV: For intermittent IV infusion, dilute to a maximum concentration of 20 mg/mL. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Hypercalcemia, Decrease in heart rate (may cause asystole) Management: If coadministration of oral calcium with oral tetracyclines cannot be avoided, consider separating administration of each agent by several hours. Calcium channel blocker toxicity, VF during cardiac resuscitation • Hyperphosphatemia: Use with caution in patients with severe hyperphosphatemia as elevated levels of phosphorus and calcium may result in soft tissue and pulmonary arterial calcium-phosphate precipitation. Note: 1 g of calcium chloride salt is equal to 273 mg of elemental calcium. Sodium thiosulfate: IV: 12.5 g over 30 minutes; may increase gradually to 25 g 3 times per week; monitor for non-anion gap acidosis, hypocalcemia, severe nausea (Reynolds 2014).