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News Staff, "Breakthrough of the year: The Runners-Up–Genetic Microsurgery for the Masses," Science (20 Dec 2013), J. Travis, "Germline editing dominates DNA summit," Science (11 Dec 2015), J. Travis, "Making the cut," Science (18 Dec 2015), Sci. J Pathol 211:188–197. “Feng Zhang is so full of creative ideas that I have no doubt that he will get one or two in the future.”, Erik Sontheimer, a CRISPR researcher at the University of Massachusetts Medical School, also endorses the Nobel committee decision. doi:10.1002/ar.22579, CAS Science 343:84–87. Hence these sequences play a key role in the antiviral (i.e. doi:10.1038/nbt.3471, Yoshimi K, Kunihiro Y, Kaneko T, Nagahora H, Voigt B, Mashimo T (2016) ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes. Sci Rep 6:21918. doi:10.1038/srep21918, Kim H, Kim J-S (2014) A guide to genome engineering with programmable nucleases. And Science’s 2015 Breakthrough of the Year is... one of the most controversial biomedical experiments of the past decade, when a Chinese scientist edited the genomes of human embryos, become a leader in other areas of CRISPR research, A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity, Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation, The new frontier of genome engineering with CRISPR-Cas9, A prudent path forward for genomic engineering and germline gene modification, Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning, A Cas9–guide RNA complex preorganized for target DNA recognition, Dynamics of CRISPR-Cas9 genome interrogation in living cells, Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage, Disabling Cas9 by an anti-CRISPR DNA mimic, A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9, CRISPR-Cas guides the future of genetic engineering, Knocking out barriers to engineered cell activity, DNA capture by a CRISPR-Cas9–guided adenine base editor, Breakthrough of the year: The Runners-Up–Genetic Microsurgery for the Masses, Editorial: Breakthrough to genome editing, ‘Base editors’ open new way to fix mutations, Largest ever research integrity survey flounders as universities refuse to cooperate, For €9500, Nature journals will now make your paper free to read, After scalding critiques of study on gender and mentorship, journal says it is reviewing the work, Breast milk contains coronavirus antibodies, study suggests, Hurricanes are retaining their strength after reaching land, study suggests, Injection of long-acting drug prevents HIV in women, Newly discovered reef is taller than a skyscraper, Public needs to prep for vaccine side effects, Potential signs of life on Venus are fading fast, Study homes in on ‘exceptional responders’ to cancer drugs, Laser fusion reactor approaches ‘burning plasma’ milestone, American Association for the Advancement of Science.