The ZnZn distance is 2.923(), while each ion lies 0.386 out of its least-squares basal plane towards the pyridyl nitrogen atom. Copyright © 2010 Konstantis F. Konidaris et al. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Yang, N.-N. Luan, L.-F. Wang, and Y.-M. Liu, “DNA Binding and cleavage activity of Ni(II) complex with all-, G. Zuber, J. C. Quada Jr., and S. M. Hecht, “Sequence selective cleavage of a DNA octanucleotide by chlorinated bithiazoles and bleomycins,”, F. R. Keene, J. It is proposed that the new compound has a monoclinic space group of P121/c1, No. https://doi.org/10.1016/j.jssc.2020.121483. Small synthetic binders can interact with DNA through the following three noncovalent modes: intercalation, groove binding, and external static electronic effects [4]. The metal center is five-coordinated surrounded by two acetylacetonate and one (3-py)CHNOH ligand. All manipulations were performed under aerobic conditions using reagents and solvents as received. Complex 1 crystallizes in the monoclinic space group . If both strands are cleaved, a linear form (form III) will be generated and migrate between forms I and II [28]. Ab initio structure determination was performed based on Synchrotron X-ray powder diffraction data. B. Baruah, “Self-assembly of neutral dinuclear and trinuclear zinc-benzoate complexes,”, V. Zeleňák, M. Sabo, W. Massa, and J. Černák, “Tetra-, H. Necefoglu, W. Clegg, and A. J. Scott, “Tetrakis(, Q. Zhou, T. W. Hambley, B. J. Kennedy et al., “Syntheses and characterization of anti-inflammatory dinuclear and mononuclear zinc indomethacin complexes. The difference , where , is 122 , less than that for NaO2CMe (164 ), as expected for bidentate bridging ligation [26]. DNA mobility shift assays were carried out to investigate the ability of complexes 1H2O and 2, as well as that of the (3-py)CHNOH free ligand to interact with plasmid DNA. The (3-py)CHNOH ligand (Figure 5, lanes 3 and 6) does not display any interaction. FCC unit cells consist of four atoms, eight eighths at the corners and six halves in the faces. The resulting colourless solution was stirred at ambient temperature for 30 min and allowed to slowly evaporate at room temperature. Among the various metal ions studied with nucleic acids and nucleobases, has occupied a special position [6], mainly due to the following reasons [7]: is a strong Lewis acid and exchanges ligands very rapidly; is of low toxicity; it has no redox chemistry, catalyzing only hydrolytic cleavage of DNA. © 2020 Elsevier Inc. All rights reserved. Ab initio structure determination from Synchrotron powder diffraction data of this phase is reported. IR data (KBr, cm): 3454 (wb), 3192 (m), 3084 (m), 2996 (m), 2962 (m), 2914 (m), 2808 (w), 1656 (sh), 1586 (vs), 1522 (s), 1400 (vs), 1340 (s), 1316 (s), 1268 (s), 1192 (w), 1124 (w), 1102 (vw), 1058 (vw), 1020 (m), 986 (s), 928 (m), 890 (w), 818 (m), 770 (m), 702 (m), 682 (w) 654 (w), 562 (w), and 418 (vw). DNA mobility shift assays were performed for the determination of the in vitro effect of both complexes on the integrity and the electrophoretic mobility of pDNA. Analysis of the shape-determining angles using the approach of Reedijk and coworkers [16] yields a trigonality index, , value of 0.53 ( and 1 for perfect sp and tbp geometries, respectively). The IR spectra of 1H2O and 2 exhibit weak bands at 3468 and 3454 cm, respectively, assignable to the (OH) vibration of the coordinated pyridyl oxime ligands [22]. Other types of DNA-binding experiments are currently in progress in order to determine the way of interaction with pDNA. The functional role of Glu77 for metal binding is unexpected, because this residue is not conserved in previously determined structures of zinc … The layered structure of the new phase is similar to Simonkolleite, with more interlayer H2O/NH3 molecules. The ions are bridged by four , :: ligands and each one has a perfect square pyramidal coordination geometry (), with the apex provided by the pyridyl nitrogen atom of a monodentate (3-py)CHNOH ligand. Lin, R.-D. Hu, and X.-H. Lu, “Synthesis, characterization and DNA-binding studies on La(III) and Ce(III) complexes containing ligand of. Zinc has a Young's modulus of 70 GPa, a yield stress of 160 MPa, an UTS of 200 MPa, and a fracture strain of 0.9. Copyright © 2020 Elsevier B.V. or its licensors or contributors. DNA is generally the primary intracellular target of anticancer drugs, so such interactions can cause damage in cancer cells, block their division and consequently result in cell death [3]. During the last decades, there has been considerable interest in the interaction of small molecules with DNA [1, 2]. Download : Download high-res image (351KB)Download : Download full-size image. Crystal Structure of the Zinc-binding Transport Protein ZnuA from Escherichia coli Reveals an Unexpected Variation in Metal Coordination. The metal is hard and brittle at most temperatures but becomes malleable between 100 and 150 °C. By continuing you agree to the use of cookies. This structure is the simple cubic crystal structure. Zinc acetylacetonate, zinc acetate, and 3-pyridinealdoxime were purchased from Aldrich Co. Elemental analyses (C, H, N) were performed by the University of Ioannina (Greece) Microanalytical Laboratory using an EA 1108 Carlo Erba analyzer. Its crystal structure consists of mononuclear molecules and H2O molecules being present in the lattice. Metals we encounter daily are formed into shapes for practical purposes, so the metal may be smooth, rough, jagged or pointy. Transition metal complexes are a particularly interesting class of DNA-binders because of their cationic character, well-defined three-dimensional structure, aptitude to perform hydrolysis and redox reactions, as well as extensively developed substitution chemistry that allows easy modulations of their binding and reactive properties [5]. It is somewhat less dense than iron and has a hexagonal crystal structure, with a distorted form of hexagonal close packing, in which each atom has six nearest neighbors (at 265.9 pm) in its own plane and six others at a greater distance of 290.6 pm. Crystal structures of [Zn, K. W. Nordquest, D. W. Phelps, W. F. Little, and D. J. Hodgson, “Metal-metal interactions in linear chains. The three most common crystalline structures in metal are face-centered cubic, body-centered cubic and hexagonal close-packed. The presence of chelating acac- ligands in complex 1H2O is reflected by the presence of two strong intensity bands at 1500–1600 .